Comparison of the Results of Radical Hysterectomy: Sequential Observations in Each Period
Background: The efficacy of drains and of antibiotics for prophylaxis of postoperative retroperitoneal infections following radical hysterectomy with systematic lymphadenectomy has not yet been adequately investigated. Methods: Patients who had just undergone radical hysterectomy were divided into t...
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Published in | Japanese journal of clinical oncology Vol. 32; no. 3; pp. 103 - 107 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Oxford University Press
01.03.2002
Oxford Publishing Limited (England) |
Subjects | |
Online Access | Get full text |
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Summary: | Background: The efficacy of drains and of antibiotics for prophylaxis of postoperative retroperitoneal infections following radical hysterectomy with systematic lymphadenectomy has not yet been adequately investigated. Methods: Patients who had just undergone radical hysterectomy were divided into three groups. We used a retroperitoneal drain transvaginally for Groups A (n = 54) and B (n = 55) and transabdominally for Group C (n = 103). Group A was administered a first- and Groups B and C a second- or third-generation cephem antibiotic as the prophylactic antibiotic. We compared the surgery time, blood loss, fever index and febrile morbidity in these three groups. Results: The average surgery time was Group A 344.2 ± 13.7 min (mean ± SE), Group B 425.6 ± 11.0 min and Group C 528.2 ± 10.9 min. A significant difference was observed among the groups (p < 0.05). In terms of blood loss during surgery, a significant increase (p < 0.05) occurred in Groups B (2400 ± 196 g) and C (2373 ± 130 g) compared with Group A (1820 ± 122 g). For fever index, Group A showed a value of 36.1 ± 2.7 dh, Group B 19.9 ± 2.4 dh and Group C 8.8 ± 1.5 dh. A significant difference was observed among the groups (p < 0.01). In terms of febrile morbidity, significant differences (p < 0.01, p < 0.0001) were observed between Groups B (14.6%) and C (8.7%) in comparison with Group A (44.4%), respectively. Conclusion: In radical hysterectomy with systematic lymphadenectomy, it may be preferable to choose transabdominal drains in the retroperitoneal space and second-generation cephem antibiotics for prophylaxis of postoperative retroperitoneal infections. |
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Bibliography: | ark:/67375/HXZ-LTP59L96-F istex:A63D86D1C84E11F4B4CCCDE4C59DA688DC792DA8 local:hyf024 Received November 2, 2001; accepted December 28, 2001. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0368-2811 1465-3621 1465-3621 |
DOI: | 10.1093/jjco/hyf024 |