Effects of non-vascularized adipose tissue transplantation on its genetic profile

Subcutaneous adipose tissue (SAT) is recognized as a highly active metabolic and inflammatory tissue. Interestingly, adipose tissue transplantation is widely performed in plastic surgery via lipofilling, yet little is known about the gene alteration of adipocytes after transplantation. We performed...

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Published inAdipocyte Vol. 10; no. 1; pp. 131 - 141
Main Authors Schreiter, Jeannine S, Kurow, L O, Langer, S, Steinert, M, Massier, L
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 01.01.2021
Taylor & Francis Group
Subjects
adipose tissue
Brief Report
fat transplantation
gene expression
gene ontology
insulin resistance
fat transplantation
gene ontology
Adipose tissue
insulin resistance
gene expression
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Summary:Subcutaneous adipose tissue (SAT) is recognized as a highly active metabolic and inflammatory tissue. Interestingly, adipose tissue transplantation is widely performed in plastic surgery via lipofilling, yet little is known about the gene alteration of adipocytes after transplantation. We performed an RNA-expression analysis of fat transplants before and after fat transplantation.In C57BL/6 N mice SAT was autologously transplanted. Samples of SAT were analysed before transplantation, 7, and 15 days after transplantation and gene expression profiles were measured.Analysis revealed that lipid metabolism-related genes were downregulated while inflammatory and extracellular matrix related genes were up-regulated 7 and 15 days after transplantation. When comparing gene expression profile 7 days after transplantation to 15 days after transplantation developmental pathways showed most changes.
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content type line 23
Stefan Langer: conception
Author credit statement
Matthias Steinert: proof reading
Lucas Massier: Conception, visualization, data analysis
Olga Kurow: Co-first author, Operating the animals, sample recovery
Jeannine Schreiter: Conception, data analyses, operation of the animals, writing
ISSN:2162-3945
2162-397X
DOI:10.1080/21623945.2021.1889815