Vascular Inflammatory Markers as Predictors of Peripheral Arterial Disease Patients' Quality-of-Life Changes after Endovascular Treatment

• Published in: Journal of clinical medicine Vol. 12; no. 10; p. 3412
• Main Authors: Wachsmann-Maga, Agnieszka, Maga, Mikołaj, Polczyk, Romuald, Włodarczyk, Aleksandra, Pasieka, Patrycja, Terlecki, Karol, Maga, Paweł
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.05.2023; MDPI
• Subjects: Angioplasty; Asthma; Atherosclerosis; Biomarkers; Blood vessels; Cardiovascular disease; Care and treatment; Clinical medicine; Coronary vessels; Diagnosis; Emotional disorders; Health aspects; Hospitalization; Inflammation; Ischemia; Laboratories; Measurement; Meetings; Mood disorders; Pain; Patient outcomes; Peripheral vascular diseases; Prognosis; Quality of life; Questionnaires; Surgery; Ultrasonic imaging; Unsaturated fatty acids; Urine; Vein & artery diseases; Poland; Japan; eicosanoids; endothelium; inflammation; thromboxanes; peripheral arterial disease; quality of life; leukotrienes
• ISSN: 2077-0383; 2077-0383
• DOI: 10.3390/jcm12103412

The association between chronic inflammation and depression, anxiety, anhedonia, and quality of life (QoL) has been recently emphasized. However, the pathophysiology of this relationship remains unsolved. This study aims to assess the dependence between vascular inflammation represented by eicosanoid concentration and quality of life in patients with peripheral arterial disease (PAD). A total of 175 patients undergoing endovascular treatment due to lower limbs ischemia were covered with eight years of observation after the endovascular procedure, including ankle-brachial index (ABI), color Doppler ultrasound examination, urinary leukotriene E4 (LTE4), thromboxane B2 (TXB2) and 5-Hydroxyeicosatetraenoic acid (5-HETE) measurement and quality-of-life assessment with VascuQol-6. The baseline concentrations of LTE4 and TXB2 reversely correlated with preoperative VascuQol-6 and were predictive of the postoperative values of VascuQol-6 at each follow-up. At every follow-up timepoint, the results of VascuQol-6 reflected the LTE4 and TXB2 concentrations. Higher concentrations of LTE4 and TXB2 were correlated with lower life quality during the next follow-up meeting. Changes in VascuQol-6 at eight years vs. preoperative values were reversely related to the preoperative concentrations of LTE4 and TXB2. This is the first study to confirm that changes in life quality in PAD patients undergoing endovascular treatment are highly dependent on eicosanoid-based vascular inflammation.