Protein Aggregation is Associated with Acinetobacter baumannii Desiccation Tolerance
Desiccation tolerance has been implicated as an important characteristic that potentiates the spread of the bacterial pathogen on dry surfaces. Here we explore several factors influencing desiccation survival of . At the macroscale level, we find that desiccation tolerance is influenced by cell dens...
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Published in | Microorganisms (Basel) Vol. 8; no. 3; p. 343 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
MDPI
28.02.2020
MDPI AG |
Subjects | |
Online Access | Get full text |
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Summary: | Desiccation tolerance has been implicated as an important characteristic that potentiates the spread of the bacterial pathogen
on dry surfaces. Here we explore several factors influencing desiccation survival of
. At the macroscale level, we find that desiccation tolerance is influenced by cell density and growth phase. A transcriptome analysis indicates that desiccation represents a unique state for
compared to commonly studied growth phases and strongly influences pathways responsible for proteostasis. Remarkably, we find that an increase in total cellular protein aggregates, which is often considered deleterious, correlates positively with the ability of
to survive desiccation. We show that inducing protein aggregate formation prior to desiccation increases survival and, importantly, that proteins incorporated into cellular aggregates can retain activity. Our results suggest that protein aggregates may promote desiccation tolerance in
through preserving and protecting proteins from damage during desiccation until rehydration occurs. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2076-2607 2076-2607 |
DOI: | 10.3390/microorganisms8030343 |