Escape of X-linked miRNA genes from meiotic sex chromosome inactivation

• Published in: Development (Cambridge) Vol. 142; no. 21; pp. 3791 - 3800
• Main Authors: Sosa, Enrique, Flores, Luis, Yan, Wei, McCarrey, John R.
• Format: Journal Article
• Language: English
• Published: England The Company of Biologists 01.11.2015
• Subjects: Animals; Chromosomes, Mammalian; In Situ Hybridization, Fluorescence; Male; Meiosis; Mice - genetics; Mice - metabolism; MicroRNAs; Spermatocytes - metabolism; Spermatogenesis; Testis - cytology; Testis - metabolism; Transcription, Genetic; X Chromosome - metabolism; X Chromosome Inactivation; Y Chromosome - metabolism; X inactivation; Meiosis; Germ cells; Epigenetic regulation; Male fertility; Spermatogenesis

Past studies indicated that transcription of all X-linked genes is repressed by Meiotic Sex Chromosome Inactivation (MSCI) during the meiotic phase of spermatogenesis in mammals. However more recent studies showed an increase in steady-state levels of certain X-linked miRNAs in pachytene spermatocyt...