Significance of modified Glasgow prognostic score as a useful indicator for prognosis of patients with gastric carcinoma

• Published in: The American journal of surgery Vol. 201; no. 2; pp. 186 - 191
• Main Authors: Nozoe, Tadahiro, M.D, Iguchi, Tomohiro, M.D, Egashira, Akinori, M.D, Adachi, Eisuke, M.D, Matsukuma, Akito, M.D, Ezaki, Takahiro, M.D
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.02.2011; Elsevier; Elsevier Limited
• Subjects: Adult; Aged; Aged, 80 and over; Biological and medical sciences; Biomarkers, Tumor - blood; C-reactive protein; C-Reactive Protein - metabolism; Carcinoma - blood; Carcinoma - diagnosis; Carcinoma - mortality; Carcinoma - pathology; Classification; Colorectal cancer; Disease; Esophageal cancer; Female; Gastric cancer; Gastric carcinoma; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Humans; Indicators; Inflammation; Inflammation - blood; Inflammation - diagnosis; Inflammation-based prognostic score; Kaplan-Meier Estimate; Laboratories; Lymphatic Metastasis; Lymphatic system; Male; Medical prognosis; Medical sciences; Metastasis; Middle Aged; Multivariate analysis; Neoplasm Invasiveness; Patients; Postoperative period; Predictive Value of Tests; Prognosis; Proteins; Risk Factors; Serum Albumin - metabolism; Severity of Illness Index; Stomach Neoplasms - blood; Stomach Neoplasms - diagnosis; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Surgery; Tumors; Veins - pathology; Gastric carcinoma; Inflammation-based prognostic score; Prognosis; Human; Biological indicator; Patient; Inflammation; Malignant tumor; Stomach cancer; Medicine; Stomach carcinoma; Score; Treatment; Surgery; Digestive diseases; Cancer; Gastric disease
• ISSN: 0002-9610; 1879-1883
• DOI: 10.1016/j.amjsurg.2010.01.030

Abstract Background The significance of the Glasgow prognostic score (GPS), an inflammation-based prognostic score, as an indicator of aggressiveness in gastric carcinoma has not been investigated fully. Methods Two hundred thirty-two patients with gastric carcinoma were enrolled. Patients who had both an elevated C-reactive protein (>1.0 mg/dL) and hypoalbuminemia (<3.5 g/dL) were allocated a traditional GPS (TGPS) of 2. Patients who had one of these abnormal values were allocated a TGPS of 1, and patients who had neither were allocated a TGPS of 0. Results There existed a significant difference between the survival of adjacent groups of patients when examined using the TGPS ( P = .05 for TGPS 0 vs 1 and P = .006 for TGPS 1 vs 2). Multivariate analysis based on TGPS demonstrated that TGPS ( P = .020) and tumor stage ( P = .0007) proved to be independent prognostic indicators for worse prognosis. Conclusions The preoperative measurement of an inflammation-based prognostic score can demonstrate a strict stratification for the prognosis of patients with gastric carcinoma.