AMPA Receptor Trafficking and Synaptic Plasticity

▪ Abstract  Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we r...

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Bibliographic Details
Published inAnnual review of neuroscience Vol. 25; no. 1; pp. 103 - 126
Main Authors Malinow, Roberto, Malenka, Robert C.
Format Journal Article
LanguageEnglish
Published Palo Alto, CA Annual Reviews 01.01.2002
Annual Reviews, Inc
Subjects
Animals
Biological and medical sciences
Central nervous system
Electrophysiology
Fundamental and applied biological sciences. Psychology
Hippocampus - cytology
Hippocampus - metabolism
Humans
Long-Term Potentiation - physiology
Memory - physiology
Neural Inhibition - physiology
Neuronal Plasticity - physiology
Protein Transport - physiology
Receptors, AMPA - metabolism
Synaptic Transmission - physiology
Vertebrates: nervous system and sense organs
Potentiation
AMPA receptor
Synaptic transmission
Synaptic plasticity
Synaptic depression
Glutamate receptor
Review
Long term
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Summary:▪ Abstract  Activity-dependent changes in synaptic function are believed to underlie the formation of memories. Two prominent examples are long-term potentiation (LTP) and long-term depression (LTD), whose mechanisms have been the subject of considerable scrutiny over the past few decades. Here we review the growing literature that supports a critical role for AMPA receptor trafficking in LTP and LTD, focusing on the roles proposed for specific AMPA receptor subunits and their interacting proteins. While much work remains to understand the molecular basis for synaptic plasticity, recent results on AMPA receptor trafficking provide a clear conceptual framework for future studies.
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ISSN:0147-006X
1545-4126
DOI:10.1146/annurev.neuro.25.112701.142758