Pseudo-outbreaks of Stenotrophomonas maltophilia on an intensive care unit in England

• Published in: The Journal of hospital infection Vol. 92; no. 4; pp. 392 - 396
• Main Authors: Waite, T.D, Georgiou, A, Abrishami, M, Beck, C.R
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2016
• Subjects: Adult; Aged; Aged, 80 and over; Bronchoalveolar Lavage Fluid - microbiology; Bronchoscope; Bronchoscopes - microbiology; Cohort Studies; Contamination; Cross Infection - epidemiology; Cross Infection - microbiology; Disease Outbreaks; England - epidemiology; Female; Gram-Negative Bacterial Infections - epidemiology; Gram-Negative Bacterial Infections - microbiology; Hospitals, District; Hospitals, General; Humans; Infectious Disease; Intensive care unit; Intensive Care Units; Male; Middle Aged; Pseudo-outbreak; Risk Assessment; Stenotrophomonas maltophilia; Stenotrophomonas maltophilia - isolation & purification; United Kingdom > UK; England; Stenotrophomonas maltophilia; Pseudo-outbreak; Bronchoscope; Contamination; Intensive care unit
• ISSN: 0195-6701; 1532-2939
• DOI: 10.1016/j.jhin.2015.12.014

Summary Background In June 2014, a cluster of identical S. maltophilia isolates was reported in an adult intensive care unit (ICU) at a district general hospital. An outbreak control team was convened to investigate the cluster and inform control measures. Aim To identify potential risk factors for isolation of S. maltophilia in this setting. Methods We conducted a cohort study of ICU patients for whom a bronchoalveolar lavage (BAL) specimen was submitted between October 2013 and October 2014. Cases were patients with S. maltophilia -positive BAL. We calculated the association between isolation of S. maltophilia and patient characteristics using risk ratios (RRs) with 95% confidence intervals (95% CIs) and univariate logistic regression. Chi-squared or Fisher's exact tests were used. BAL specimens were microbiologically typed using pulse-field gel electrophoresis (PFGE). Findings Eighteen patients met the case definition. Two patients had clinical presentations that warranted antibiotic treatment for S. maltophilia . All cases were exposed to bronchoscopy. PFGE typing revealed clusters of two strain types. We found statistically significant elevated risks of isolating BRISPOSM-4 in patients exposed to bronchoscope A (RR: 13.56; 95% CI: 1.82–100; P  < 0.001) and BRISPOSM-3 in patients exposed to bronchoscope B (RR: 16.89; 95% CI: 2.14–133; P  < 0.001). S. maltophilia type BRISPOSM-4 was isolated in water used to flush bronchoscope A after decontamination. Conclusion Two pseudo-outbreaks occurred in which BAL specimens had been contaminated by reusable bronchoscopes. We cannot exclude the potential for colonization of the lower respiratory tract of exposed patients. Introduction of single-use bronchoscopes was an effective control measure.