Affinity and enzyme-based biosensors: recent advances and emerging applications in cell analysis and point-of-care testing

The applications of biosensors range from environmental testing and biowarfare agent detection to clinical testing and cell analysis. In recent years, biosensors have become increasingly prevalent in clinical testing and point-of-care testing. This is driven in part by the desire to decrease the cos...

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Bibliographic Details
Published inAnalytical and bioanalytical chemistry Vol. 404; no. 4; pp. 1181 - 1196
Main Authors Liu, Ying, Matharu, Zimple, Howland, Michael C., Revzin, Alexander, Simonian, Aleksandr L.
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer-Verlag 01.09.2012
Springer
Subjects
Affinity
Analysis
Analytical Chemistry
Antibodies
Aptamers, Nucleotide - chemistry
Biochemistry
Biosensing Techniques - economics
Biosensing Techniques - methods
Biosensing Techniques - trends
Biosensors
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Diagnostic Tests, Routine - economics
Diagnostic Tests, Routine - methods
Diagnostic Tests, Routine - trends
Environmental testing
Enzymes
Enzymes - chemistry
Focusing
Food Science
Health care
Humans
Laboratory Medicine
Mathematical analysis
Medical care, Cost of
Medical equipment
Monitoring/Environmental Analysis
Physicians
Physiological apparatus
Point-of-Care Systems - economics
Review
Enzyme
Point of care
Biosensor
Aptamers
Phage
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Summary:The applications of biosensors range from environmental testing and biowarfare agent detection to clinical testing and cell analysis. In recent years, biosensors have become increasingly prevalent in clinical testing and point-of-care testing. This is driven in part by the desire to decrease the cost of health care, to shift some of the analytical tests from centralized facilities to “frontline” physicians and nurses, and to obtain more precise information more quickly about the health status of a patient. This article gives an overview of recent advances in the field of biosensors, focusing on biosensors based on enzymes, aptamers, antibodies, and phages. In addition, this article attempts to describe efforts to apply these biosensors to clinical testing and cell analysis. Figure Biosensor for Point of care
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ISSN:1618-2642
1618-2650
1618-2650
DOI:10.1007/s00216-012-6149-6