Current Approaches of Bone Morphogenetic Proteins in Dentistry

Bone morphogenic proteins (BMPs) are a group of osteoinductive proteins obtained from nonmineralized bone matrix; they are capable of stimulating the differentiation of pluripotent mesenchymal cells to osteoprogenitor cells. They have become a likely treatment option, given their action on regenerat...

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Published inThe Journal of oral implantology Vol. 41; no. 3; pp. 337 - 342
Main Authors Díaz-Sánchez, Rosa-María, Yáñez-Vico, Rosa-María, Fernández-Olavarría, Ana, Mosquera-Pérez, Regina, Iglesias-Linares, Alejandro, Torres-Lagares, Daniel
Format Journal Article
LanguageEnglish
Published United States Allen Press Inc 01.06.2015
Subjects
Bone Morphogenetic Protein 2
Bone Morphogenetic Proteins
Bone Regeneration
Cell Differentiation
Defects
Dentin
Dentistry
FDA approval
Genetic engineering
Insulin-like growth factors
Mineralization
Osteogenesis
Proteins
Sinuses
Studies
Tissue engineering
Transforming Growth Factor beta
bone regeneration
periodontal regeneration
bone morphogenetic proteins
dental regeneration
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Summary:Bone morphogenic proteins (BMPs) are a group of osteoinductive proteins obtained from nonmineralized bone matrix; they are capable of stimulating the differentiation of pluripotent mesenchymal cells to osteoprogenitor cells. They have become a likely treatment option, given their action on regeneration and remodeling of bone lesions and increasing the bone response around alloplastic materials. It may be feasible in the near future for BMPs to replace autologous and allogenic bone grafts. The application of specific growth factors for osteoinduction without using a bone graft constitutes a real impact on bone regeneration. The use of BMP is not only focused on osteogenic regeneration: There are a variety of studies investigating other properties, such as periodontal or dental regeneration from the conservative viewpoint. In this review, we will highlight the role of the BMP in bone, periodontal and dental regeneration.
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ISSN:0160-6972
1548-1336
DOI:10.1563/aaid-joi-d-13-00012