Contribution of concentration-sensitive sodium channels to the absorption of alveolar fluid in mice

• Published in: Respiratory physiology & neurobiology Vol. 231; pp. 45 - 54
• Main Authors: Hagiwara, Teruki, Yoshida, Shigeru
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2016
• Subjects: Acid Sensing Ion Channel Blockers - pharmacology; Adsorption - drug effects; Adsorption - physiology; Alveolar type II epithelial cell; Amiloride; Amiloride - pharmacology; Animals; Body Fluids - drug effects; Body Fluids - metabolism; Concentration-sensitive sodium channel; Endothelial Cells - cytology; Endothelial Cells - metabolism; Extracellular Space - drug effects; Extracellular Space - metabolism; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; In Situ Hybridization; Male; Medical Education; Mice, Inbred ICR; Microscopy, Immunoelectron; Microvessels - cytology; Microvessels - metabolism; Pulmonary Alveoli - blood supply; Pulmonary Alveoli - cytology; Pulmonary Alveoli - growth & development; Pulmonary Alveoli - metabolism; Pulmonary microvascular endothelial cell; Pulmonary/Respiratory; Real-Time Polymerase Chain Reaction; RNA, Messenger - metabolism; Sodium - metabolism; Sodium Channels - metabolism; Sodium transport; Concentration-sensitive sodium channel; Pulmonary microvascular endothelial cell; Sodium transport; Amiloride; Alveolar type II epithelial cell
• ISSN: 1569-9048; 1878-1519
• DOI: 10.1016/j.resp.2016.05.017

Highlights • NaC expression is associated with LWC during development in mice. • NaC is expressed in AEC II and PMVECs in mouse lung. • Elevation of [Na+ ]o increased [Na+ ]i in the alveolar wall in the presence of amiloride.