Dosimetric evaluation of nuclear interaction models in the Geant4 Monte Carlo simulation toolkit for carbon-ion radiotherapy

We tested the ability of two separate nuclear reaction models, the binary cascade and JQMD (Jaeri version of Quantum Molecular Dynamics), to predict the dose distribution in carbon-ion radiotherapy. This was done by use of a realistic simulation of the experimental irradiation of a water target. Com...

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Published inRadiological physics and technology Vol. 1; no. 2; pp. 183 - 187
Main Authors Kameoka, S., Amako, K., Iwai, G., Murakami, K., Sasaki, T., Toshito, T., Yamashita, T., Aso, T., Kimura, A., Kanai, T., Kanematsu, N., Komori, M., Takei, Y., Yonai, S., Tashiro, M., Koikegami, H., Tomita, H., Koi, T.
Format Journal Article
LanguageEnglish
Published Tokyo Springer Japan 01.07.2008
Subjects
Algorithms
Carbon - chemistry
Computer Simulation
Humans
Imaging
Ions
Medical and Radiation Physics
Medicine
Medicine & Public Health
Models, Biological
Monte Carlo Method
Nuclear Medicine
Radiology
Radiometry - instrumentation
Radiometry - methods
Radiotherapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - instrumentation
Radiotherapy Planning, Computer-Assisted - methods
Water - chemistry
Carbon-ion radiotherapy
Geant4
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ISSN1865-0333
1865-0341
1865-0341
DOI10.1007/s12194-008-0026-1

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Summary:We tested the ability of two separate nuclear reaction models, the binary cascade and JQMD (Jaeri version of Quantum Molecular Dynamics), to predict the dose distribution in carbon-ion radiotherapy. This was done by use of a realistic simulation of the experimental irradiation of a water target. Comparison with measurement shows that the binary cascade model does a good job reproducing the spread-out Bragg peak in depth-dose distributions in water irradiated with a 290 MeV/u (per nucleon) beam. However, it significantly overestimates the peak dose for a 400 MeV/u beam. JQMD underestimates the overall dose because of a tendency to break a nucleus into lower- Z fragments than does the binary cascade model. As far as shape of the dose distribution is concerned, JQMD shows fairly good agreement with measurement for both beam energies of 290 and 400 MeV/u, which favors JQMD over the binary cascade model for the calculation of the relative dose distribution in treatment planning.
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ISSN:1865-0333
1865-0341
1865-0341
DOI:10.1007/s12194-008-0026-1