Role of Exosomal Non-Coding RNA in the Tumour Microenvironment of Genitourinary System Tumours

• Published in: Technology in Cancer Research & Treatment Vol. 22; p. 15330338231198348
• Main Authors: Wu, Shuang, Mu, Chao, Sun, Jia-jia, Hu, Xin-rong, Yao, Yun-hong
• Format: Book Review Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.01.2023; Sage Publications Ltd; SAGE Publishing
• Subjects: Body fluids; Cervical cancer; Diagnosis; Exosomes; Humans; Lipid bilayers; Metastases; Neoplasms; Non-coding RNA; Quality of Life; RNA, Untranslated - genetics; Tumor microenvironment; Tumor Microenvironment - genetics; Tumors; Urogenital System; tumour microenvironment; non-coding RNA; exosome; cervical cancer; tumor
• ISSN: 1533-0346; 1533-0338
• DOI: 10.1177/15330338231198348

In recent years, genitourinary system tumors are common in people of all ages, seriously affecting the quality of life of patients, the pathogenesis and treatment of these diseases are constantly being updated and improved. Exosomes, with a lipid bilayer that enable delivery of their contents into body fluids or other cells. Exosomes can regulate the tumor microenvironment, and play an important role in tumor development. In turn, cellular and non-cellular components of tumor microenvironment also affect the occurrence, progression, invasion and metastasis of tumor. Non-coding RNAs have been shown to be able to be ingested and released by exosomes, and are seen as a potential tool in cancer diagnosis and treatment. Here, we summarize the effect of non-coding RNAs of exosome contents on the tumor microenvironment of genitourinary system tumor, expound the significance of non-coding RNAs of exosome in the occurrence, development, diagnosis and treatment of cancers.