A Multigene Signature Associated with Progression-Free Survival after Treatment for IDH Mutant and 1p/19q Codeleted Oligodendrogliomas

• Published in: Cancers Vol. 15; no. 12; p. 3067
• Main Authors: Gilhodes, Julia, Meola, Adèle, Cabarrou, Bastien, Peyraga, Guillaume, Dehais, Caroline, Figarella-Branger, Dominique, Ducray, François, Maurage, Claude-Alain, Loussouarn, Delphine, Uro-Coste, Emmanuelle, Cohen-Jonathan Moyal, Elizabeth, Pola Network
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.06.2023; MDPI
• Subjects: Algorithms; Analysis; Biochemistry, Molecular Biology; Biomarkers; Brain cancer; Brain tumors; Cancer; Care and treatment; Chemotherapy; Development and progression; Extracellular matrix; Gene expression; Genes; Genomes; Genomics; Glioma; Gliomas; Life Sciences; Medical prognosis; Molecular biology; Multivariate analysis; Mutants; Neurobiology; Neurons and Cognition; Patients; Physiological aspects; Prognosis; Radiation therapy; RNA; Statistical analysis; Survival; Tumors; Vincristine; France; glioma; gene signature; 1p/19q codeletion; treatment response
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15123067

IDH mutant and 1p/19q codeleted oligodendrogliomas are the gliomas associated with the best prognosis. However, despite their sensitivity to treatment, patient survival remains heterogeneous. We aimed to identify gene expressions associated with response to treatment from a national cohort of patients with oligodendrogliomas, all treated with radiotherapy +/- chemotherapy. We extracted total RNA from frozen tumor samples and investigated enriched pathways using KEGG and Reactome databases. We applied a stability selection approach based on subsampling combined with the lasso-pcvl algorithm to identify genes associated with progression-free survival and calculate a risk score. We included 68 patients with oligodendrogliomas treated with radiotherapy +/- chemotherapy. After filtering, 1697 genes were obtained, including 134 associated with progression-free survival: 35 with a better prognosis and 99 with a poorer one. Eight genes (ST3GAL6, QPCT, NQO1, EPHX1, CST3, S100A8, CHI3L1, and OSBPL3) whose risk score remained statistically significant after adjustment for prognostic factors in multivariate analysis were selected in more than 60% of cases were associated with shorter progression-free survival. We found an eight-gene signature associated with a higher risk of rapid relapse after treatment in patients with oligodendrogliomas. This finding could help clinicians identify patients who need more intensive treatment.