Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction

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Bibliographic Details
Published inJournal of hepatology Vol. 64; no. 6; pp. 1274 - 1282
Main Authors Shi, Xiao-Lei, Mancham, Shanta, Hansen, Bettina E, de Knegt, Robert J, de Jonge, Jeroen, van der Laan, Luc J.W, Rivadeneira, Fernando, Metselaar, Herold J, Kwekkeboom, Jaap
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2016
Subjects
Adolescent
Adult
Aged
B7-H1 Antigen - antagonists & inhibitors
B7-H1 Antigen - genetics
B7-H1 Antigen - physiology
Co-inhibition
Female
Gastroenterology and Hepatology
Genetic polymorphism
Genotype
Graft rejection
Graft Rejection - etiology
Humans
Interferon-gamma - pharmacology
Liver transplantation
Liver Transplantation - adverse effects
Lymphocyte Activation
Male
Middle Aged
PD-1
PD-L1
Polymorphism, Single Nucleotide
Programmed Cell Death 1 Receptor - antagonists & inhibitors
Programmed Cell Death 1 Receptor - genetics
Programmed Cell Death 1 Receptor - physiology
T lymphocytes
T-Lymphocytes - immunology
Tolerance
Young Adult
peripheral blood mononuclear cells
T lymphocytes
programmed death 1 receptor
calcineurin inhibitor
single nucleotide polymorphism
LT
Tolerance
carboxyfluorescein succinimidyl ester
CFSE
PBMC
Co-inhibition
Graft rejection
SNP
cytotoxic T lymphocyte antigen 4
HWE
Genetic polymorphism
PD-L1
CTLA-4
PD-1
dendritic cell
liver transplantation
CNI
DC
Hardy Weinberg Equilibrium
Liver transplantation
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Summary:Graphical abstract
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0168-8278
1600-0641
DOI:10.1016/j.jhep.2016.02.034