A Systematic Review of Individualized Heart Surgery with a Personalized Prosthesis

• Published in: Journal of personalized medicine Vol. 13; no. 10; p. 1483
• Main Authors: Sazzad, Faizus, Ramanathan, Kollengode, Moideen, Irwan Shah, Gohary, Abdulrahman El, Stevens, John Carey, Kofidis, Theo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.10.2023; MDPI
• Subjects: Computed tomography; Congenital diseases; CT imaging; Customization; Design; Echocardiography; Finite element method; Health aspects; Heart surgery; Implants, Artificial; Mathematical models; Medical equipment; Medical research; Medical Subject Headings-MeSH; Medicine, Experimental; Patients; Pharmacogenetics; Precision medicine; Prostheses; Prosthesis; Review; Surgeons; Surgery; Surgical techniques; Systematic review; Therapeutic applications; implantation; open-heart surgery; individualized; systematic review; personalized
• ISSN: 2075-4426; 2075-4426
• DOI: 10.3390/jpm13101483

Personalized surgery is not just a new trend but rather a patient-specific approach to therapy that makes it possible to adopt a targeted approach for a specific patient and closely mirrors the approach of personalized medicine. However, the application of tailored surgery in the context of cardiovascular replacement surgery has not been systematically reviewed. The ability to customize a device is highly dependent on the collection of radiological image data for precise prosthesis modeling. These facts are essential to "tailor-made" device design for precise prosthesis implantation. According to this study, computed tomography (CT) was the most prominent imaging modality; however, transesophageal echocardiography and echocardiography were also found to be helpful. Additionally, a dynamic finite element simulation was also found to be an attractive alternative to the finite element analysis for an in-silico experiment. Nonetheless, there is a paucity of relevant publications and only sporadic evidence. More clinical studies have been warranted, notwithstanding that the derived data and results from this insight into the use of therapeutic interventions may be evidence of multiple directives in clinical practices and beyond. This study may help the integration of personalized devices for better comprehension of predicted clinical outcomes, thus leading towards enhanced performance gains.