When stem cells grow old: phenotypes and mechanisms of stem cell aging

All multicellular organisms undergo a decline in tissue and organ function as they age. An attractive theory is that a loss in stem cell number and/or activity over time causes this decline. In accordance with this theory, aging phenotypes have been described for stem cells of multiple tissues, incl...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 143; no. 1; pp. 3 - 14
Main Authors Schultz, Michael B, Sinclair, David A
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 01.01.2016
Subjects
Aging - physiology
Animals
Cell Survival - physiology
Cellular Senescence - physiology
Humans
Longevity - physiology
Review
Stem Cells - physiology
Telomere Shortening - physiology
Multicellular organisms
Hematopoietic stem cells
Age-related diseases
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Summary:All multicellular organisms undergo a decline in tissue and organ function as they age. An attractive theory is that a loss in stem cell number and/or activity over time causes this decline. In accordance with this theory, aging phenotypes have been described for stem cells of multiple tissues, including those of the hematopoietic system, intestine, muscle, brain, skin and germline. Here, we discuss recent advances in our understanding of why adult stem cells age and how this aging impacts diseases and lifespan. With this increased understanding, it is feasible to design and test interventions that delay stem cell aging and improve both health and lifespan.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.130633