Is transcranial sonography useful for diagnosing Parkinson's disease in clinical practice?

Transcranial sonography (TCS) is an emerging ancillary examination for diagnosing Parkinson's disease (PD). To evaluate TCS features in patients with PD and its mimics, and establish their accuracy in predicting the final clinical diagnosis after follow-up. We retrospectively studied 85 patient...

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Published inArquivos de neuro-psiquiatria Vol. 76; no. 7; pp. 459 - 466
Main Authors Grippe, Talyta Cortez, Allam, Nasser, Brandão, Pedro Renato de Paula, Pereira, Danilo Assis, Cardoso, Francisco Eduardo Costa, Aguilar, Ana Carolina Rodrigues, Kessler, Iruena Moraes
Format Journal Article
LanguageEnglish
Portuguese
Published Brazil Arquivos de Neuro-Psiquiatria 01.07.2018
Academia Brasileira de Neurologia - ABNEURO
Academia Brasileira de Neurologia (ABNEURO)
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Summary:Transcranial sonography (TCS) is an emerging ancillary examination for diagnosing Parkinson's disease (PD). To evaluate TCS features in patients with PD and its mimics, and establish their accuracy in predicting the final clinical diagnosis after follow-up. We retrospectively studied 85 patients with an initial clinical suspicion of PD, atypical parkinsonism or essential tremor, all of whom underwent TCS. Two specialists reviewed the follow-up clinical visit records and determined the final clinical diagnosis. The accuracy analysis of the TCS was determined using Bayesian statistical methods. The finding of substantia nigra hyperechogenicity (> 20 mm2) showed high sensitivity (93.4%) and specificity (86.6%). The positive likelihood ratio showed 6.93-fold greater odds for diagnosing PD than an alternative condition when this finding was present. This study revealed the practical usefulness of TCS in differentiating PD from its prevalent mimics when the clinical diagnosis was initially unclear.
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ISSN:0004-282X
1678-4227
1678-4227
DOI:10.1590/0004-282x20180067