Ferroptosis-Related Gene SLC1A5 Is a Novel Prognostic Biomarker and Correlates with Immune Microenvironment in HBV-Related HCC

(1) Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with limited treatment satisfaction. Finding new therapeutic targets has remained a major challenge. Ferroptosis is an iron-dependent cell death program that plays a regulatory role in HBV infection and HCC de...

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Published inJournal of clinical medicine Vol. 12; no. 5; p. 1715
Main Authors Su, Hanwen, Liu, Youyi, Huang, Jingtao
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.02.2023
MDPI
Subjects
Biological markers
Biomarkers
Cancer
Cell death
Clinical medicine
Complications and side effects
Development and progression
Disease
Ferroptosis
Gene expression
Genetic aspects
Health aspects
Hepatitis B
Hepatitis C
Hepatoma
Infections
Liver cancer
Medical prognosis
Oncology, Experimental
Pathogenesis
Prognosis
Regression analysis
Risk factors
Software
Survival analysis
China
HCC
ferroptosis-related gene
SLC1A5
tumor microenvironment
HBV
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Summary:(1) Background: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide with limited treatment satisfaction. Finding new therapeutic targets has remained a major challenge. Ferroptosis is an iron-dependent cell death program that plays a regulatory role in HBV infection and HCC development. It is necessary to classify the roles of ferroptosis or ferroptosis-related genes (FRGs) in HBV-related HCC progression. (2) Methods: We conducted a matched case–control study from the TCGA database, retrospectively collecting demographic data and common clinical indicators from all subjects. The Kaplan–Meier curve, univariate and multivariate cox regression analysis of the FRGs were used to explore the risk factors for HBV-related HCC. The CIBERSORT algorithm and TIDE algorithm were executed to evaluate the functions of FRGs in the tumor-immune environment. (3) Results: A total of 145 HBV-positive HCC patients and 266 HBV-negative HCC patients were enrolled in our study. Four ferroptosis related genes (FANCD2, CS, CISD1 and SLC1A5) were positively correlated with the progression of HBV-related HCC. Among them, SLC1A5 was an independent risk factor for HBV-related HCC, and correlated with poor prognosis, advanced progression and an immunosuppression microenvironment. (4) Conclusions: Here, we revealed that a ferroptosis-related gene, SLC1A5, may be an excellent predictor of HBV-related HCC and may provide insight into the development of innovative possible therapeutic techniques.
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These authors contributed equally to this work.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12051715