Science is 1% inspiration and 99% biomarkers

Neurodegeneration plays a key role in multiple sclerosis (MS) contributing to long-term disability in patients. The prognosis is, however, unpredictable coloured by complex disease mechanisms which can only be clearly appreciated using biomarkers specific to pathobiology of the underlying process. H...

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Bibliographic Details
Published inMultiple sclerosis Vol. 23; no. 11; p. 1442
Main Authors Dubuisson, Nicolas, Puentes, Fabiola, Giovannoni, Gavin, Gnanapavan, Sharmilee
Format Journal Article
LanguageEnglish
Published England 01.10.2017
Subjects
Biomarkers
Humans
Multiple Sclerosis - diagnosis
tau
Neurodegenerative biomarkers
neurofilament antibodies
chitinase and chitinase-like proteins
multiple sclerosis
neurofilaments
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Summary:Neurodegeneration plays a key role in multiple sclerosis (MS) contributing to long-term disability in patients. The prognosis is, however, unpredictable coloured by complex disease mechanisms which can only be clearly appreciated using biomarkers specific to pathobiology of the underlying process. Here, we describe six promising neurodegenerative biomarkers in MS (neurofilament proteins, neurofilament antibodies, tau, N-acetylaspartate, chitinase and chitinase-like proteins and osteopontin), critically evaluating the evidence using a modified Bradford Hill criteria.
ISSN:1477-0970
DOI:10.1177/1352458517709362