ATP-dependent chromatin remodeling during mammalian development

Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin and, hence, regulate gene expression. These...

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Bibliographic Details
Published inDevelopment (Cambridge) Vol. 143; no. 16; pp. 2882 - 2897
Main Authors Hota, Swetansu K, Bruneau, Benoit G
Format Journal Article
LanguageEnglish
Published England The Company of Biologists Ltd 15.08.2016
Subjects
Adenosine Triphosphate - metabolism
Animals
Chromatin - metabolism
Chromatin Assembly and Disassembly - genetics
Chromatin Assembly and Disassembly - physiology
Embryonic Development - genetics
Embryonic Development - physiology
Humans
Review
Chromatin remodeler
Transcription
Differentiation
Gene expression
Chromatin remodeling
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Summary:Precise gene expression ensures proper stem and progenitor cell differentiation, lineage commitment and organogenesis during mammalian development. ATP-dependent chromatin-remodeling complexes utilize the energy from ATP hydrolysis to reorganize chromatin and, hence, regulate gene expression. These complexes contain diverse subunits that together provide a multitude of functions, from early embryogenesis through cell differentiation and development into various adult tissues. Here, we review the functions of chromatin remodelers and their different subunits during mammalian development. We discuss the mechanisms by which chromatin remodelers function and highlight their specificities during mammalian cell differentiation and organogenesis.
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ISSN:0950-1991
1477-9129
DOI:10.1242/dev.128892