Toward site-specific, homogeneous and highly stable fluorescent silver nanoclusters fabrication on triplex DNA scaffolds

A new strategy to create site-specific, homogeneous, and bright silver nanoclusters (AgNCs) with high-stability was demonstrated by triplex DNA as template. By reasonable design of DNA sequence, homogeneous Ag(2) cluster was obtained in the predefined position of CG.C(+) site of triplex DNA. This st...

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Bibliographic Details
Published inNucleic acids research Vol. 40; no. 16; p. e122
Main Authors Feng, Lingyan, Huang, Zhenzhen, Ren, Jinsong, Qu, Xiaogang
Format Journal Article
LanguageEnglish
Published England Oxford University Press 01.09.2012
Subjects
DNA - chemistry
Fluorescent Dyes - chemistry
Methods Online
Nanostructures - chemistry
Nanostructures - ultrastructure
Nucleation
Nucleotide sequence
Salts
scaffolds
Silver
Silver - chemistry
Spectrometry, Mass, Electrospray Ionization
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Summary:A new strategy to create site-specific, homogeneous, and bright silver nanoclusters (AgNCs) with high-stability was demonstrated by triplex DNA as template. By reasonable design of DNA sequence, homogeneous Ag(2) cluster was obtained in the predefined position of CG.C(+) site of triplex DNA. This strategy was also explored for controlled alignment of AgNCs on the DNA nanoscaffold. To the best of our knowledge, this was the first example to simultaneously answer the challenges of excellent site-specific nucleation and growth, homogeneity and stability against salt of DNA-templated AgNCs.
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The authors wish it to be known that, in their opinion, the first two authors should be regarded as joint First Authors.
ISSN:0305-1048
1362-4962
1362-4962
DOI:10.1093/nar/gks387