Autoantibodies in primary sclerosing cholangitis

The aetiology of primary sclerosing cholangitis （PSC） is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients, but the specificity of these antibodies is generally low, and the frequencies...

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Published inWorld journal of gastroenterology : WJG Vol. 14; no. 24; pp. 3781 - 3791
Main Authors Hov, Johannes-Roksund, Boberg, Kirsten-Muri, Karlsen, Tom-H
Format Journal Article
LanguageEnglish
Published United States Medical Department,Rikshospitalet University Hospital,Oslo N-0027,Norway 28.06.2008
The WJG Press and Baishideng
Subjects
Autoantibodies - blood
Autoimmune Diseases - blood
Autoimmune Diseases - immunology
Biomarkers - blood
Cholangitis, Sclerosing - immunology
Epithelial Cells - immunology
Humans
Neutrophils - immunology
原肌球蛋白
嗜中性粒细胞
硬化性胆管炎
自身免疫性
自身抗体
Primary sclerosing cholangitis
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Summary:The aetiology of primary sclerosing cholangitis （PSC） is not known and controversy exists as to whether PSC should be denominated an autoimmune disease. A large number of autoantibodies have been detected in PSC patients, but the specificity of these antibodies is generally low, and the frequencies vary largely between different studies. The presence of autoantibodies in PSC may be the result of a nonspecific dysregulation of the immune system, but the literature in PSC points to the possible presence of specific antibody targets in the biliary epithelium and in neutrophil granulocytes. The present review aims to give an overview of the studies of autoantibodies in PSC, with a particular emphasis on the prevalence, clinical relevance and possible pathogenetic importance of each individual marker.
Bibliography:Primary sclerosing cholangitis,Autoantibodies, Autoimmunity; Antibodies againstcytoplasmic constituents of neutrophil, Tropomyosin
Antibodies againstcytoplasmic constituents of neutrophil, Tropomyosin
R575.6
Primary sclerosing cholangitis,Autoantibodies, Autoimmunity
14-1219/R
SourceType-Scholarly Journals-1
ObjectType-Commentary-2
content type line 23
ObjectType-Review-1
ObjectType-Editorial-3
Correspondence to: Tom H Karlsen, MD, PhD, Medical department, Rikshospitalet University Hospital, Oslo N-0027, Norway. t.h.karlsen@klinmed.uio.no
Author contributions: Hov JR and Karlsen TH searched the literature for relevant articles and wrote the paper. Boberg KM critically evaluated and edited the manuscript. All authors approved of the final manuscript.
Telephone: +47-23-072469
Fax: +47-23-073510
ISSN:1007-9327
2219-2840
DOI:10.3748/wjg.14.3781