Inflammation and thrombosis in cardiovascular disease

This article will summarize recent observations that provide mechanistic insight into the molecular and cellular links between inflammation and thrombosis in the context of cardiovascular and other thromboinflammatory disease states. Several disease conditions are characterized by a thromboinflammat...

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Bibliographic Details
Published inCurrent opinion in hematology Vol. 20; no. 5; p. 457
Main Authors Nagareddy, Prabhakara, Smyth, Susan S
Format Journal Article
LanguageEnglish
Published United States 01.09.2013
Subjects
Animals
Anti-Inflammatory Agents - therapeutic use
Blood Platelets - physiology
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - physiopathology
Fibrinolytic Agents - therapeutic use
Humans
Inflammation - physiopathology
Neutrophils - physiology
Thrombosis - physiopathology
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Summary:This article will summarize recent observations that provide mechanistic insight into the molecular and cellular links between inflammation and thrombosis in the context of cardiovascular and other thromboinflammatory disease states. Several disease conditions are characterized by a thromboinflammatory state in which interactions of blood cells and components with the vascular wall perpetuate both thrombotic and inflammatory pathways. Targeting these pathways may be of benefit in inflammatory conditions and cardiovascular disease. Ongoing clinical trials should provide additional insight into the hypothesis that the thromboinflammatory state contributes to adverse clinical outcomes.
ISSN:1531-7048
DOI:10.1097/MOH.0b013e328364219d