Efficacy of the Combination Sodium Ceftiofur-Flumethasone in the Treatment of Experimental Pasteurella haemolytica Bronchopneumonia in Calves

• Published in: Journal of veterinary medicine. Series A Vol. 44; no. 1-10; pp. 179 - 187
• Main Authors: Sustronck, B., Deprez, P., Loon, G. Van, Coghe, J., Muylle, E.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.05.1997
• Subjects: Animals; Anti-Inflammatory Agents - therapeutic use; Bronchoalveolar Lavage - veterinary; Cattle; Cephalosporins - therapeutic use; Drug Therapy, Combination; Female; Flumethasone - therapeutic use; Granulocytes; Leukocyte Count; Male; Mannheimia haemolytica; Pasteurellosis, Pneumonic - drug therapy
• ISSN: 0931-184X; 0514-7158; 1439-0442
• DOI: 10.1111/j.1439-0442.1997.tb01099.x

Summary Severe acute bronchopneumonia was induced in 18 conventional Friesian‐Holstein calves by inoculating them intratracheally with Pasteurella haemolytica type Al. Six of the calve received no treatment and served as controls. Six of the calves were treated with sodium ceftiofur and six were treated with sodium ceftiofur and flumethasone. The mortality rate in the group of calves treated with sodium ceftiofur and flumethasone was significantly lower and their clinical and haematological parameters returned to normal significantly faster than in the control calves and the calves treated with sodium ceftiofur alone.