Involvement of Adenylyl Cyclase Signaling Mechanism in Insulin and IGF-I Coregulation of Fundamental Cell Processes

: The discovery of the adenylyl cyclase signaling mechanism (ACSM) of insulin and related peptides allows for advancing the hypothesis of its participation in regulatory action on cell growth, apoptosis, and metabolism. The following evidences were obtained: (1) The order of efficiency of insulin an...

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Published inAnnals of the New York Academy of Sciences Vol. 1040; no. 1; pp. 429 - 430
Main Author PERTSEVA, M.N
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.04.2005
Subjects
3T3 Cells
Activation
adenylyl cyclase
Adenylyl Cyclases - physiology
Animals
Apoptosis
cell growth
Cell Physiological Phenomena
Glycogens
Humans
IGF-I
Insulin
Insulin - physiology
Insulin-Like Growth Factor I - physiology
Metabolism
Mice
Pathways
Peptides
Signal Transduction - physiology
Synthesis
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Summary:: The discovery of the adenylyl cyclase signaling mechanism (ACSM) of insulin and related peptides allows for advancing the hypothesis of its participation in regulatory action on cell growth, apoptosis, and metabolism. The following evidences were obtained: (1) The order of efficiency of insulin and IGF‐I growth‐promoting action and their antiapoptotic effect coincides with that of the peptide‐activating action on AC. (2) The growth‐promoting and antiapoptotic effects of insulin and IGF‐I are distinctly reproduced by cAMP. (3) The anabolic effects of insulin and IGF‐I activation on glycogen synthesis and the pentosophosphate pathway are inhibited by cAMP.
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ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1327.081