Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications

• Published in: Advanced materials (Weinheim) Vol. 22; no. 45; pp. 5168 - 5172
• Main Authors: Liong, Monty, Shao, Huilin, Haun, Jered B., Lee, Hakho, Weissleder, Ralph
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 01.12.2010; WILEY‐VCH Verlag
• Subjects: cell labeling; Cell Line, Tumor; Ferric Compounds - chemistry; Humans; Hydrogen-Ion Concentration; iron oxide; magnetic resonance; Magnetics; Manganese Compounds - chemistry; Methylation; nanocrystals; Nanoparticles - chemistry; Nanoparticles - ultrastructure; Nanotechnology - methods; Neoplasms - diagnosis; Osmolar Concentration; polyvinyl alcohol; Polyvinyl Alcohol - chemistry; Temperature

Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non‐cross‐linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer‐coated NCs exhibit low nonspecific cell binding. They are also amenable to chemica...