Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications

Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non‐cross‐linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer‐coated NCs exhibit low nonspecific cell binding. They are also amenable to chemica...

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Bibliographic Details
Published inAdvanced materials (Weinheim) Vol. 22; no. 45; pp. 5168 - 5172
Main Authors Liong, Monty, Shao, Huilin, Haun, Jered B., Lee, Hakho, Weissleder, Ralph
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 01.12.2010
WILEY‐VCH Verlag
Subjects
cell labeling
Cell Line, Tumor
Ferric Compounds - chemistry
Humans
Hydrogen-Ion Concentration
iron oxide
magnetic resonance
Magnetics
Manganese Compounds - chemistry
Methylation
nanocrystals
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanotechnology - methods
Neoplasms - diagnosis
Osmolar Concentration
polyvinyl alcohol
Polyvinyl Alcohol - chemistry
Temperature
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Summary:Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non‐cross‐linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer‐coated NCs exhibit low nonspecific cell binding. They are also amenable to chemical linking with biomolecules, allowing for the efficient labeling of surface receptors on targeted cancer cells in vitro.
Bibliography:ArticleID:ADMA201002219
istex:B4DD5E102A283ABEB72CABB29C77A1200E2C2014
ark:/67375/WNG-9KZSD6TS-F
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.201002219