Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications
Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non‐cross‐linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer‐coated NCs exhibit low nonspecific cell binding. They are also amenable to chemica...
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| Published in | Advanced materials (Weinheim) Vol. 22; no. 45; pp. 5168 - 5172 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Weinheim
WILEY-VCH Verlag
01.12.2010
WILEY‐VCH Verlag |
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| Abstract | Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non‐cross‐linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer‐coated NCs exhibit low nonspecific cell binding. They are also amenable to chemical linking with biomolecules, allowing for the efficient labeling of surface receptors on targeted cancer cells in vitro. |
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| AbstractList | Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non‐cross‐linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under varying temperatures, pH, and ionic strengths. The polymer‐coated NCs exhibit low nonspecific cell binding. They are also amenable to chemical linking with biomolecules, allowing for the efficient labeling of surface receptors on targeted cancer cells in vitro. |
| Author | Liong, Monty Lee, Hakho Haun, Jered B. Shao, Huilin Weissleder, Ralph |
| Author_xml | – sequence: 1 givenname: Monty surname: Liong fullname: Liong, Monty organization: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA) – sequence: 2 givenname: Huilin surname: Shao fullname: Shao, Huilin organization: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA) – sequence: 3 givenname: Jered B. surname: Haun fullname: Haun, Jered B. organization: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA) – sequence: 4 givenname: Hakho surname: Lee fullname: Lee, Hakho email: hlee@mgh.harvard.edu organization: Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, 185 Cambridge Street, Boston, Massachusetts, 02114 (USA) – sequence: 5 givenname: Ralph surname: Weissleder fullname: Weissleder, Ralph email: rweissleder@mgh.harvard.edu organization: Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts, 02115 (USA) |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20859943$$D View this record in MEDLINE/PubMed |
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| Snippet | Highly magnetic MnFe2O4 nanocrystals (NCs) are coated with non‐cross‐linked carboxymethyl polyvinyl alcohol to produce conjugates that are highly stable under... |
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| SubjectTerms | cell labeling Cell Line, Tumor Ferric Compounds - chemistry Humans Hydrogen-Ion Concentration iron oxide magnetic resonance Magnetics Manganese Compounds - chemistry Methylation nanocrystals Nanoparticles - chemistry Nanoparticles - ultrastructure Nanotechnology - methods Neoplasms - diagnosis Osmolar Concentration polyvinyl alcohol Polyvinyl Alcohol - chemistry Temperature |
| Title | Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications |
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