Effect of penicillin on the increase in membrane conductance induced by γ‐aminobutyric acid at the crab neuromuscular junction

The effects of penicillin and picrotoxin on the increase in membrane conductance produced by gamma-aminobutyric acid (GABA) at the hermit crab neuromuscular junction were investigated. Penicillin failed to block the effects of GABA, while picrotoxin proved to be a potent antagonist.

Saved in:
Bibliographic Details
Published inBritish journal of pharmacology Vol. 48; no. 2; pp. 318 - 320
Main Authors Earl, Janet, Large, W. A.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.06.1973
Subjects
Aminobutyrates - pharmacology
Animals
Brachyura
Dose-Response Relationship, Drug
Drug Interactions
Electric Stimulation
In Vitro Techniques
Membranes - drug effects
Muscles - drug effects
Neural Conduction - drug effects
Neuromuscular Junction - drug effects
Penicillin G - pharmacology
Penicillins - pharmacology
Picrotoxin - pharmacology
Short Communications
Online AccessGet full text

Cover

More Information
Summary:The effects of penicillin and picrotoxin on the increase in membrane conductance produced by gamma-aminobutyric acid (GABA) at the hermit crab neuromuscular junction were investigated. Penicillin failed to block the effects of GABA, while picrotoxin proved to be a potent antagonist.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1973.tb06919.x