The assay of anti‐pyretic drugs in mice, using intracerebral injection of pyretogenins

1 A simple, cheap, and reliable method is described for the screening of new compounds for anti‐pyretic activity. It involves the intracerebral injection of a suitable pyretogenin in conscious mice. 2 The pyretic response is related to the logarithm of the dose in a substantially linear manner when...

Full description

Saved in:
Bibliographic Details
Published inBritish journal of pharmacology Vol. 34; no. 1; pp. 148 - 158
Main Authors CASHIN, C. H., HEADING, CHRISTINE E.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.1968
Subjects
Acetaminophen - pharmacology
Analgesics - pharmacology
Animals
Antipyrine - pharmacology
Aspirin - pharmacology
Biological Assay
Body Temperature - drug effects
Cerebral Ventricles
Female
Fever - chemically induced
Flufenamic Acid - pharmacology
Indomethacin - pharmacology
Injections
Male
Mefenamic Acid - pharmacology
Methods
Mice - metabolism
Phenylacetates - pharmacology
Phenylbutazone - pharmacology
Pyrogens
Rabbits
Typhoid-Paratyphoid Vaccines
Online AccessGet full text

Cover

More Information
Summary:1 A simple, cheap, and reliable method is described for the screening of new compounds for anti‐pyretic activity. It involves the intracerebral injection of a suitable pyretogenin in conscious mice. 2 The pyretic response is related to the logarithm of the dose in a substantially linear manner when “E” Pyrogen is used. 3 A selection of established anti‐pyretic drugs were effective in oral doses approaching those used clinically, which shows that the method is unusually sensitive. 4 The response to intracerebral pyretogenin is not unduly influenced by drugs known to cause hypothermia. 5 It is suggested that “E” Pyrogen injected intracerebrally has a direct effect on the central nervous system, rather than an indirect action through release of endogenous pyrogen.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1968.tb07958.x