Consumption of Vitamin B6 Reduces Fecal Ratio of Lithocholic Acid to Deoxycholic Acid, a Risk Factor for Colon Cancer, in Rats Fed a High-Fat Diet

To examine the effect of supplemental dietary vitamin B6 on the colonic luminal environment, growing male rats were fed a high-fat diet containing 1, 7, or 35 mg pyridoxine HCl/kg diet for 6 wk. Food intake and growth were unaffected by the dietary treatment. Supplemental dietary vitamin B6 signific...

Full description

Saved in:
Bibliographic Details
Published inJournal of Nutritional Science and Vitaminology Vol. 58; no. 5; pp. 366 - 370
Main Authors OKAZAKI, Yukako, UTAMA, Zaki, SUIDASARI, Sofya, ZHANG, Peipei, YANAKA, Noriyuki, TOMOTAKE, Hiroyuki, SAKAGUCHI, Ei, KATO, Norihisa
Format Journal Article
LanguageEnglish
Published Tokyo Center for Academic Publications Japan 2012
Subjects
Biological and medical sciences
colonic luminal environment
Feeding. Feeding behavior
Fundamental and applied biological sciences. Psychology
high-fat diet
rats
Vertebrates: anatomy and physiology, studies on body, several organs or systems
vitamin B6
Rat
Vitamin
Colon cancer
Intestinal disease
Ratio
Colon
rats
vitamin B
Digestive system
Gut
Rodentia
Malignant tumor
Feeding
colonic luminal environment
Colonic disease
Vertebrata
Mammalia
Diet
Food intake
Animal
Risk factor
high-fat diet
Fat
Digestive diseases
Cancer
Online AccessGet full text

Cover

More Information
Summary:To examine the effect of supplemental dietary vitamin B6 on the colonic luminal environment, growing male rats were fed a high-fat diet containing 1, 7, or 35 mg pyridoxine HCl/kg diet for 6 wk. Food intake and growth were unaffected by the dietary treatment. Supplemental dietary vitamin B6 significantly reduced the production of a fecal secondary bile acid, lithocholic acid (the most toxic secondary bile acid and a risk factor for colon cancer), and markedly reduced the ratio of lithocholic acid to deoxycholic acid (a less toxic secondary bile acid) in feces (p<0.05). Increasing dietary vitamin B6 increased fecal mucin levels (a marker of intestinal barrier function) in a dose-dependent manner (p<0.05) but did not affect fecal immunoglobulin A levels (an index of intestinal immune function). Cecal levels of organic acids were not significantly affected by supplemental dietary vitamin B6. These results suggest the possibility that dietary vitamin B6 affects the colonic luminal environment by altering the production of secondary bile acids and mucins.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ISSN:0301-4800
1881-7742
DOI:10.3177/jnsv.58.366