Amido-Bridged Nucleic Acids (AmNAs): Synthesis, Duplex Stability, Nuclease Resistance, and in Vitro Antisense Potency

Towards the next generation: New LNA analogues based on a cyclic amide structure, termed amido‐bridged nucleic acids (AmNAs), have been synthesized. Oligonucleotides modified with these residues showed high nuclease resistance along with high binding affinities towards complementary strands.

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Bibliographic Details
Published inChembiochem : a European journal of chemical biology Vol. 13; no. 17; pp. 2513 - 2516
Main Authors Yahara, Aiko, Shrestha, Ajaya Ram, Yamamoto, Tsuyoshi, Hari, Yoshiyuki, Osawa, Takashi, Yamaguchi, Masaki, Nishida, Masaru, Kodama, Tetsuya, Obika, Satoshi
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 26.11.2012
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
Subjects
Amides - chemistry
Apolipoproteins B - genetics
Base Sequence
Biochemistry & Molecular Biology
bridged nucleic acids
Cell Line
Chemistry Techniques, Synthetic
Chemistry, Medicinal
Humans
Life Sciences & Biomedicine
nuclease resistance
oligonucleotides
Oligonucleotides - chemical synthesis
Oligonucleotides - chemistry
Oligonucleotides - genetics
Oligonucleotides - metabolism
Oligonucleotides, Antisense - chemical synthesis
Oligonucleotides, Antisense - chemistry
Oligonucleotides, Antisense - genetics
Oligonucleotides, Antisense - metabolism
Pharmacology & Pharmacy
Phosphoric Diester Hydrolases - metabolism
Science & Technology
synthesis design
thermal stability
Transition Temperature
bridged nucleic acids
NUCLEOSIDE ANALOGS
2'-AMINO-LNA
RECOGNITION
RNA
thermal stability
THYMINE
oligonucleotides
CONFORMATION
nuclease resistance
DNA
ENA
synthesis design
LNA
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Summary:Towards the next generation: New LNA analogues based on a cyclic amide structure, termed amido‐bridged nucleic acids (AmNAs), have been synthesized. Oligonucleotides modified with these residues showed high nuclease resistance along with high binding affinities towards complementary strands.
Bibliography:istex:1EEE7D584BD73D48C7810C0BA1321C37D92BF287
Program for Promotion of Fundamental Studies in Health Sciences of the National Institute of Biomedical Innovation (NIBIO)
ark:/67375/WNG-D1PRPM0L-X
ArticleID:CBIC201200506
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.201200506