Mechanized Silica Nanoparticles Based on Pillar[5]arenes for On-Command Cargo Release

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 9; no. 19; pp. 3224 - 3229
• Main Authors: Sun, Yu-Long, Yang, Ying-Wei, Chen, Dai-Xiong, Wang, Guan, Zhou, Yue, Wang, Chun-Yu, Stoddart, J. Fraser
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 11.10.2013; WILEY‐VCH Verlag; Wiley Subscription Services, Inc
• Subjects: Binding; cargo release; Derivatives; drug delivery; Nanocomposites; Nanomaterials; Nanoparticles; Nanostructure; Nanotechnology; pillar[n]enes; Porosity; silica nanoparticles; Silicon dioxide; cargo release; pillar[n]enes; drug delivery; silica nanoparticles

Mechanized silica nanoparticles, equipped with pillar[5]arene‐[2]pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading...