Mechanized Silica Nanoparticles Based on Pillar[5]arenes for On-Command Cargo Release

Mechanized silica nanoparticles, equipped with pillar[5]arene‐[2]pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 9; no. 19; pp. 3224 - 3229
Main Authors Sun, Yu-Long, Yang, Ying-Wei, Chen, Dai-Xiong, Wang, Guan, Zhou, Yue, Wang, Chun-Yu, Stoddart, J. Fraser
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 11.10.2013
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
Subjects
Binding
cargo release
Derivatives
drug delivery
Nanocomposites
Nanomaterials
Nanoparticles
Nanostructure
Nanotechnology
pillar[n]enes
Porosity
silica nanoparticles
Silicon dioxide
cargo release
pillar[n]enes
drug delivery
silica nanoparticles
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Summary:Mechanized silica nanoparticles, equipped with pillar[5]arene‐[2]pseudorotaxane nanovalves, operate in biological media to trap cargos within their nanopores, but release them when the pH is lowered or a competitive binding agent is added. Although cargo size plays an important role in cargo loading, cargo charge‐type does not appear to have any significant influence on the amount of cargo loading or its release. These findings open up the possibility of using pillar[n]arene and its derivatives for the formation of robust and dynamic nanosystems that are capable of performing useful functions.
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ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201300445