Acute renal effects of doxazosin in man

To evaluate the role of alpha 1‐adrenoceptors in the regulation of renal blood flow and renin secretion, we infused doxazosin in incremental doses (group I, n = 5) or at a fixed rate of 1 microgram kg‐ 1 min‐1 (group II, n = 6) into the renal artery of hypertensive patients just prior to diagnostic...

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Published inBritish journal of clinical pharmacology Vol. 21; no. S1; pp. 41S - 43S
Main Authors Leeuw, PW, Es, PN, Bos, R, Birkenhager, WH
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.01.1986
Subjects
Adult
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Doxazosin
Humans
Kidney - drug effects
Kidney - metabolism
Male
Middle Aged
Pharmacology of Doxazosin
Physical Exertion
Prazosin - analogs & derivatives
Prazosin - pharmacology
Renal Circulation - drug effects
Renin - blood
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Summary:To evaluate the role of alpha 1‐adrenoceptors in the regulation of renal blood flow and renin secretion, we infused doxazosin in incremental doses (group I, n = 5) or at a fixed rate of 1 microgram kg‐ 1 min‐1 (group II, n = 6) into the renal artery of hypertensive patients just prior to diagnostic renal angiography. In group I, stepwise increasing doses of doxazosin were associated with increases in renal perfusion and, at doses above 1 microgram kg‐1 min‐1, also with a fall in blood pressure. Compared with observations in control subjects, doxazosin enhanced renal renin release at rest but did not modify the renin response to isometric exercise in group II. alpha 1‐ Adrenoceptors are involved in causing renal vasoconstriction and inhibition of renin secretion. However, the latter is only of importance in resting subjects.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0306-5251
1365-2125
DOI:10.1111/j.1365-2125.1986.tb02852.x