Symptomatology, prognosis, and clinical findings of Monkeypox infected patients during COVID‐19 era: A systematic‐review
Background The recent outbreak of Human Monkeypox (MPXV) in nonendemic regions of the world is of great concern. Objective We aimed to systematically analyze the current epidemiology, clinical presentation, and outcomes of the Monkeypox virus. Method Systematic literature was conducted in PubMed, Em...
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Published in | Immunity, Inflammation and Disease Vol. 10; no. 11; pp. e722 - n/a |
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Main Authors | , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
John Wiley & Sons, Inc
01.11.2022
Wiley |
Subjects | |
Online Access | Get full text |
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Summary: | Background
The recent outbreak of Human Monkeypox (MPXV) in nonendemic regions of the world is of great concern.
Objective
We aimed to systematically analyze the current epidemiology, clinical presentation, and outcomes of the Monkeypox virus.
Method
Systematic literature was conducted in PubMed, Embase, Google Scholar, and Scopus using predefined MESH terms by using “AND” and “OR.” The following search terms were used: Monkeypox [MeSH] OR “Monkeypox virus” [MeSH] OR “POX” OR “Monkeypox” AND “Outbreak” AND “Outcomes” from December 2019 till 14th June 2022 without restrictions of language.
Results
A total of 1074 (99.90%) patients tested positive for Monkeypox virus through RT‐PCR while 1 (0.09) patient was suspected. There was a gender difference with male predominance (54.23% vs. 45.48%) compared with female patients. Mean age (±SD) of patients was 20.66 ± 16.45 years. The major symptoms were rash (100%), fever (96%), and other important symptoms were upper respiratory symptoms (97%), headache (95%), vomiting (95%), oral ulcers (96%), conjunctivitis (96%) and lymphadenopathy (85%). The average mean duration of treatment was 5 days, while the mean hospitalization duration was 13.3 ± 6.37 days. The outcome of 20 patients was available, 19 of 20 patients recovered fully from monkeypox, however, 1 patient was not able to survive resulting in death.
Conclusion
The recent monkeypox virus outbreak has shown that the virus could transmit in ways that were not previously expected. Further research is needed to understand the possible outcomes and association with humans and their different organ systems.
The results of this review indicate that recent cases of Monkeypox have been occurring in adults and not only in children. The symptoms were as expected with a predominance of rash, fever, headache, upper respiratory symptoms, and lymphadenopathy. Transmission of the disease can be either by contact with infectious sores, scabs, or body fluids or respiratory droplets, similarly to COVID‐19, therefore, similar preventative measures can prevent the disease from becoming epidemic/pandemic |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Undefined-3 |
ISSN: | 2050-4527 2050-4527 |
DOI: | 10.1002/iid3.722 |