Effect of Japanese radish (Raphanus sativus) sprout (Kaiware-daikon) on carbohydrate and lipid metabolisms in normal and streptozotocin-induced diabetic rats

• Published in: Phytotherapy research Vol. 20; no. 4; pp. 274 - 278
• Main Authors: Taniguchi, H, Kobayashi-Hattori, K, Tenmyo, C, Kamei, T, Uda, Y, Sugita-Konishi, Y, Oishi, Y, Takita, T
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.04.2006; Wiley
• Subjects: Animals; Biological and medical sciences; carbohydrate metabolism; Carbohydrate Metabolism - drug effects; diabetes; Diabetes Mellitus - prevention & control; Diabetes Mellitus, Experimental - drug therapy; General pharmacology; Hypoglycemic Agents - analysis; hypoglycemic effect; Japanese radish sprout; lipid metabolism; Lipid Metabolism - drug effects; Male; Medical sciences; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Phytotherapy; Plant Preparations - pharmacology; Plant Preparations - therapeutic use; Raphanus; Rats; Rats, Wistar; Seedlings; streptozotocin; Asia; Japan; Endocrinopathy; Antineoplastic agent; Rat; carbohydrate metabolism; Lipids; Raphanus sativus; Medicinal plant; Hypoglycemic agent; Cruciferae; Dicotyledones; Angiospermae; Japanese radish sprout; Carbohydrate; lipid metabolism: hypoglycemic effect; Streptozotocin; Pharmacognosy; Diabetes mellitus; Rodentia; Metabolism; Vertebrata; Antibiotic; Mammalia; Vegetable crop; Animal; Plant origin; Spermatophyta; Pharmacokinetics; diabetes
• ISSN: 0951-418X; 1099-1573
• DOI: 10.1002/ptr.1851

No information is available about the effects of Japanese radish sprout (JRS) on diabetes. To clarify the effects, the influence of JRS on carbohydrate and lipid metabolisms was investigated in normal and streptozotocin‐induced diabetic rats. The rats were fed a diet containing 0%, 2.5% or 5% of JRS ad libitum for 21 days. Compared with the corresponding control groups, the JRS‐fed normal rats showed lower plasma levels of total cholesterol (TC), triglycerides (TG), phospholipids (PL), fructosamine, glucose and insulin and higher plasma levels of low‐density lipoprotein‐cholesterol, whereas the JRS‐fed diabetic rats showed lower plasma levels of fructosamine, glucose and insulin without changes in the plasma lipid parameters. JRS also decreased the hepatic TC, TG and PL levels in the normal rats and the TG level in the diabetic rats. These results showed that JRS had a hypoglycemic activity in both the normal and diabetic rats and partly improved lipid metabolism in the normal rats. JRS has the potential to alleviate hyperglycemia in cases where diabetes is present and to serve in the primary prevention of diabetes mellitus. Copyright © 2006 John Wiley & Sons, Ltd.