Exercise Training Lowers Plasma Visfatin Concentrations in Patients with Type 1 Diabetes

• Published in: The journal of clinical endocrinology and metabolism Vol. 91; no. 11; pp. 4702 - 4704
• Main Authors: Haider, Dominik G, Pleiner, Johannes, Francesconi, Mario, Wiesinger, Günther F, Müller, Markus, Wolzt, Michael
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.11.2006; Copyright by The Endocrine Society
• Subjects: Adult; Biological and medical sciences; Blood Glucose - analysis; Cytokines - blood; Diabetes Mellitus, Type 1 - blood; Diabetes Mellitus, Type 1 - therapy; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Exercise - physiology; Exercise Therapy; Female; Fundamental and applied biological sciences. Psychology; Humans; Longitudinal Studies; Male; Medical sciences; Middle Aged; Nicotinamide Phosphoribosyltransferase; Vertebrates: endocrinology; Endocrinopathy; Physical exercise; Human; Immunopathology; Type 1 diabetes; Autoimmune disease; Endocrinology; Blood plasma
• ISSN: 0021-972X; 1945-7197
• DOI: 10.1210/jc.2006-1013

Context: Exercise training exerts beneficial effects on metabolic and vascular risk factors in patients with type 1 diabetes mellitus (T1DM). It is unknown whether training also influences concentrations of visfatin, a novel insulin-mimetic adipocytokine. Objectives: In this study, we have investigated whether plasma visfatin concentrations are altered by training in patients with T1DM. Design and Patients: Fasting plasma visfatin concentrations and metabolic parameters were measured in 18 patients with T1DM who participated in a supervised aerobic exercise program for 4 months. Three subjects discontinued training prematurely after 2 months. Samples were obtained before and during training and 8 months after the end of regular exercise. Fourteen healthy young subjects served as controls. Results: At baseline, patients with T1DM had higher visfatin concentrations than controls (64.1 ± 12.0 vs. 1.3 ± 0.0 ng/ml, P < 0.01). Exercise reduced visfatin after 2 and 4 months to 27.8 ± 2.6 (n = 18) and 17.5 ± 3.4 ng/ml (n = 15), respectively (P < 0.001 for n = 15 subjects who participated in all visits, ANOVA). This effect was maintained 8 months after cessation of training, with visfatin concentrations of 19.7 ± 5.0 ng/ml (n = 15). Metabolic parameters were not affected by the training program. Conclusion: Elevated visfatin concentrations in patients with T1DM can be lowered by regular physical exercise. It is unknown whether glucose tolerance is affected by changes in visfatin concentrations.