Single-shot regional anesthesia for laparoscopic cholecystectomies: a systematic review and network meta-analysis

• Published in: Korean journal of anesthesiology Vol. 76; no. 1; pp. 34 - 46
• Main Authors: De Cassai, Alessandro, Sella, Nicolò, Geraldini, Federico, Tulgar, Serkan, Ahiskalioglu, Ali, Dost, Burhan, Manfrin, Silvia, Karapinar, Yunus Emre, Paganini, Greta, Beldagli, Muzeyyen, Luoni, Vittoria, Ordulu, Busra Burcu Kucuk, Boscolo, Annalisa, Navalesi, Paolo
• Format: Journal Article
• Language: English
• Published: Korea (South) Korean Society of Anesthesiologists 01.02.2023; 대한마취통증의학회
• Subjects: Adult; Analgesics, Opioid; Anesthesia, Conduction; cholecystectomy; Cholecystectomy, Laparoscopic - adverse effects; Cholecystectomy, Laparoscopic - methods; Clinical; conduction anesthesia; Humans; laparoscopic cholecystectomy; laparoscopy; local anesthesia; meta-analysis; Network Meta-Analysis; Pain, Postoperative - drug therapy; Pain, Postoperative - prevention & control; Postoperative Nausea and Vomiting - epidemiology; Postoperative Nausea and Vomiting - prevention & control; 마취과학; Cholecystectomy; Conduction anesthesia; Laparoscopy; Laparoscopic cholecystectomy; Local anesthesia; Meta-analysis
• ISSN: 2005-6419; 2005-7563
• DOI: 10.4097/kja.22366

Different regional anesthesia (RA) techniques have been used for laparoscopic cholecystectomy (LC), but there is no consensus on their comparative effectiveness. Our objective was to evaluate the effect of RA techniques on patients undergoing LC using a network meta-analysis approach. We conducted a systematic review and network meta-analysis. We searched PubMed, the Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, and Web of Science (Science and Social Science Citation Index) using the following PICOS criteria: (P) adult patients undergoing LC; (I) any RA single-shot technique with injection of local anesthetics; (C) placebo or no intervention; (O) postoperative opioid consumption expressed as morphine milligram equivalents (MME), rest pain at 12 h and 24 h post-operation, postoperative nausea and vomiting (PONV), length of stay; and (S) randomized controlled trials. A total of 84 studies were included. With the exception of the rectus sheath block (P = 0.301), the RA techniques were superior to placebo at reducing opioid consumption. Regarding postoperative pain, the transversus abdominis plane (TAP) block (-1.80 on an 11-point pain scale) and erector spinae plane (ESP) block (-1.33 on an 11-point pain scale) were the most effective at 12 and 24 h. The TAP block was also associated with the greatest reduction in PONV. RA techniques are effective at reducing intraoperative opioid use, postoperative pain, and PONV in patients undergoing LC. Patients benefit the most from the bilateral paravertebral, ESP, quadratus lumborum, and TAP blocks.