Imaging and spectroscopic methods to investigate adult neurogenesis in vivo: New models and new avenues

Adult neurogenesis (AN) can be defined as the birth and development of new neurons in adulthood. Until the 1990s, AN was deemed not to happen after birth. Gradually, several groups demonstrated that specific zones of the brain of various species had a neurogenic potential. AN could be the key to tre...

Full description

Saved in:
Bibliographic Details
Published inFrontiers in neuroscience Vol. 16; p. 933947
Main Authors Just, Nathalie, Chevillard, Pierre-Marie, Migaud, Martine
Format Journal Article
LanguageEnglish
Published Frontiers 05.08.2022
Frontiers Media S.A
Subjects
adult neurogenesis
animal models
controversy
diffusion
human brain
Life Sciences
MRI
Neurobiology
Neurons and Cognition
Neuroscience
adult neurogenesis MRI animal models human brain controversy di usion MRS
adult neurogenesis
animal models
human brain
diffusion
MRI
di usion
controversy
MRS
Online AccessGet full text

Cover

More Information
Summary:Adult neurogenesis (AN) can be defined as the birth and development of new neurons in adulthood. Until the 1990s, AN was deemed not to happen after birth. Gradually, several groups demonstrated that specific zones of the brain of various species had a neurogenic potential. AN could be the key to treating a large range of neurodegenerative, neuropsychiatric, and metabolic diseases, with a better understanding of the mechanisms allowing for regeneration of new neurons. Despite this promising prospect, the existence of AN has not been validated in vivo in humans and therefore remains controversial. Moreover, the weight of AN-induced plasticity against other mechanisms of brain plasticity is not known, adding to the controversy. In this review, we would like to show that recent technical advances in brain MR imaging methods combined with improved models can resolve the debate.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
Reviewed by: Vassiliy Tsytsarev, University of Maryland, College Park, United States
This article was submitted to Brain Imaging Methods, a section of the journal Frontiers in Neuroscience
Edited by: Xi-Nian Zuo, Beijing Normal University, China
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2022.933947