Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of...

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Published inNutrients Vol. 15; no. 16; p. 3630
Main Authors Son, Joe Eun, Jo, Jay-Young, Kim, San, Park, Min Ju, Lee, Yerin, Park, Seong Shil, Park, Shin Young, Jung, Su Myung, Jung, Sung Keun, Kim, Ji Yeon, Byun, Sanguine
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.08.2023
MDPI
Subjects
AMPK
Diet
extraction optimization
Functional foods & nutraceuticals
hepatosteatosis
Hyperlipidemia
lipid metabolism
Lipids
Liver
Metabolism
rice bran extract
South Korea
St Louis Missouri
United States > US
Online AccessGet full text

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Abstract Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran.
AbstractList Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran.
Audience Academic
Author Jo, Jay-Young
Byun, Sanguine
Park, Min Ju
Kim, Ji Yeon
Son, Joe Eun
Park, Shin Young
Park, Seong Shil
Lee, Yerin
Jung, Su Myung
Jung, Sung Keun
Kim, San
AuthorAffiliation 2 Department of Biotechnology, Yonsei University, Seoul 03722, Republic of Korea; jayyjo@yonsei.ac.kr (J.-Y.J.); syparksy@yonsei.ac.kr (S.Y.P.)
4 Research Institute of Tailored Food Technology, Kyungpook National University, Daegu 41566, Republic of Korea
6 Department of Biological Sciences, Sungkyunkwan University (SKKU), Suwon 16419, Republic of Korea
3 School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Republic of Korea
5 Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea
1 Program in Developmental & Stem Cell Biology, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; joeeun.son@sickkids.ca
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Snippet Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in...
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SubjectTerms AMPK
Diet
extraction optimization
Functional foods & nutraceuticals
hepatosteatosis
Hyperlipidemia
lipid metabolism
Lipids
Liver
Metabolism
rice bran extract
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Title Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling
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