Rice Bran Extract Suppresses High-Fat Diet-Induced Hyperlipidemia and Hepatosteatosis through Targeting AMPK and STAT3 Signaling

• Published in: Nutrients Vol. 15; no. 16; p. 3630
• Main Authors: Son, Joe Eun, Jo, Jay-Young, Kim, San, Park, Min Ju, Lee, Yerin, Park, Seong Shil, Park, Shin Young, Jung, Su Myung, Jung, Sung Keun, Kim, Ji Yeon, Byun, Sanguine
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2023; MDPI
• Subjects: AMPK; Diet; extraction optimization; Functional foods & nutraceuticals; hepatosteatosis; Hyperlipidemia; lipid metabolism; Lipids; Liver; Metabolism; rice bran extract; South Korea; St Louis Missouri; United States > US
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu15163630

Rice bran, a by-product of rice milling, is abundant in bioactive molecules and is highly recognized for its health-promoting properties, particularly in improving metabolic conditions. Building on this knowledge, we aimed to optimize the extraction conditions to maximize the functional efficacy of rice bran extract (RBE) and further validate its impact on lipid metabolism. We found that the optimized RBE (ORBE) significantly suppressed high-fat diet-induced weight gain, hyperlipidemia, and hepatosteatosis in mouse models. ORBE treatment not only suppressed lipid uptake in vivo, but also reduced lipid accumulation in HepG2 cells. Importantly, we discovered that ORBE administration resulted in activation of AMPK and inhibition of STAT3, which are both crucial players in lipid metabolism in the liver. Collectively, ORBE potentially offers promise as a dietary intervention strategy against hyperlipidemia and hepatosteatosis. This study underlines the value of optimized extraction conditions in enhancing the functional efficacy of rice bran.