Biocompatibility Evaluation of Epiphany/Resilon Root Canal Filling System in Subcutaneous Tissue of Rats

• Published in: Journal of endodontics Vol. 36; no. 1; pp. 110 - 114
• Main Authors: Garcia, Lucas da Fonseca Roberti, DDS, MSc, Marques, André Augusto Franco, DDS, PhD, Roselino, Lourenço de Moraes Rego, DDS, Pires-de-Souza, Fernanda de Carvalho Panzeri, DDS, PhD, Consani, Simonides, DDS, PhD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 2010
• Subjects: Animals; Biocompatibility; Biocompatible Materials; Dental Etching; dental materials; Dentistry; Endocrinology & Metabolism; Male; Materials Testing; methacrylate resin-based sealers; Rats; Root Canal Filling Materials - toxicity; root-canal filling; Subcutaneous Tissue - drug effects; Biocompatibility; root-canal filling; dental materials; methacrylate resin-based sealers
• ISSN: 0099-2399; 1878-3554
• DOI: 10.1016/j.joen.2009.09.012

Abstract Introduction The purpose of this study was to evaluate the biocompatibility of the root canal filling system Epiphany/Resilon in connective tissue of rats. Methods Fifteen rats were used, separated into 3 groups in accordance with its period of death (7, 21, 42 days). Four filled dentin tubes were implanted with the tested materials as follows: ERSP group, Epiphany/Resilon with Self-etch Primer; ER group, Epiphany/Resilon without primer; EG group, Endofill/gutta-percha points; and ET group, empty tube. After 7, 21, and 42 days, animals were killed, obtaining 5 samples per group. A grade from I–IV was used to graduate the inflammatory reaction. Results Results showed that Epiphany/Resilon (ERSP and ER groups) induced a slight (II) inflammatory reaction after 42 days. However, in ER group, in which the self-etch primer was not applied, severe (IV) to moderate (III) inflammatory reactions were observed between 7 and 21 days. When compared with the EG and ET groups, it was observed that these groups presented tissue reaction ranging from slight (II, 7 and 21 days) to no inflammation (I, 42 days). Conclusions Epiphany/Resilon root canal filling system presented satisfactory tissue reaction. It was biocompatible when tested in connective tissue of rats.