Novel chemical permeation enhancers for transdermal drug delivery

Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effect, easy use and better patient compliance. However, development of transdermal products is primarily hindered by the low permeabi...

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Published inAsian journal of pharmceutical sciences Vol. 9; no. 2; pp. 51 - 64
Main Authors Chen, Yang, Quan, Peng, Liu, Xiaochang, Wang, Manli, Fang, Liang
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.04.2014
Elsevier
Subjects
Mechanism
Permeation enhancer
Transdermal
Mechanism
Transdermal
Permeation enhancer
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Summary:Transdermal drug delivery has been accepted as a potential non-invasive route of drug administration, with advantages of prolonged therapeutic action, decreased side effect, easy use and better patient compliance. However, development of transdermal products is primarily hindered by the low permeability of the skin. To overcome this barrier effect, numerous new chemicals have been synthesized as potential permeation enhancers for transdermal drug delivery. In this review, we presented an overview of the investigations in this field, and further implications on selection or design of suitable permeation enhancers for transdermal drug delivery were also discussed.
ISSN:1818-0876
2221-285X
DOI:10.1016/j.ajps.2014.01.001