Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous Melanoma

Transforming growth factor-β (TGF-β) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-β signaling as a tumor supp...

Full description

Saved in:
Bibliographic Details
Published inAnnals of dermatology Vol. 25; no. 2; pp. 135 - 144
Main Authors Perrot, Carole Yolande, Javelaud, Delphine, Mauviel, Alain
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Dermatological Association; The Korean Society for Investigative Dermatology 01.05.2013
대한피부과학회
Subjects
Review
피부과학
TGF-beta signaling
Metastasis
Therapeutic-targets
Melanoma
Online AccessGet full text

Cover

More Information
Summary:Transforming growth factor-β (TGF-β) is a pleiotropic growth factor with broad tissue distribution that plays critical roles during embryonic development, normal tissue homeostasis, and cancer. While its cytostatic activity on normal epithelial cells initially defined TGF-β signaling as a tumor suppressor pathway, there is ample evidence indicating that TGF-β is a potent pro-tumorigenic agent, acting via autocrine and paracrine mechanisms to promote peri-tumoral angiogenesis, together with tumor cell migration, immune escape, and dissemination to metastatic sites. This review summarizes the current knowledge on the implication of TGF-β signaling in melanoma.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
G704-002233.2013.25.2.007
ISSN:1013-9087
2005-3894
DOI:10.5021/ad.2013.25.2.135