Various Types of HIV Mixed Infections in Cameroon

In order to assess the incidence of HIV mixed infection as well as to clarify the molecular epidemiology of HIV in central Africa, we investigated 43 HIVs obtained from 211 Cameroonian AC, ARC, and AIDS patients in 1994 and 1995. Part of thepolregion and part of theenvregion were phylogenetically an...

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Published inVirology (New York, N.Y.) Vol. 245; no. 1; pp. 1 - 10
Main Authors Takehisa, Jun, Zekeng, Léopold, Ido, Eiji, Mboudjeka, Innocent, Moriyama, Hiroyuki, Miura, Tomoyuki, Yamashita, Masahiro, Gürtler, Lutz G., Hayami, Masanori, Kaptué, Lazare
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 25.05.1998
Subjects
Adolescent
Adult
AIDS/HIV
Amino Acid Sequence
Cameroon - epidemiology
Female
Genes, env
Genome, Viral
HIV Infections - epidemiology
HIV Infections - virology
HIV-1 - classification
HIV-1 - genetics
HIV-2 - classification
HIV-2 - genetics
Humans
Male
Middle Aged
Molecular Sequence Data
Phylogeny
Sequence Alignment
Sequence Analysis
Cameroon
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Summary:In order to assess the incidence of HIV mixed infection as well as to clarify the molecular epidemiology of HIV in central Africa, we investigated 43 HIVs obtained from 211 Cameroonian AC, ARC, and AIDS patients in 1994 and 1995. Part of thepolregion and part of theenvregion were phylogenetically analyzed. The genotypes observed were varied: of 43 specimens, 28 (65%) were subtype A, 1 (2%) was subtype B, 2 (5%) were subtype D, 3 (7%) were subtype F, and 2 (5%) were group O. Of the remaining 7 specimens, 3 were mixed infections with HIV-1 subtypes A and C, HIV-1 subtypes C and F, and HIV-2 subtype A and HIV-1 subtype A; 1 was a mixed infection with HIV-1 subtypes A and D and the highly divergent group O (triple infection); another 3 appeared to consist of mosaic genomes (A/G, A/E, and B/A recombinant). These data show that various types of mixed infection, such as between different subtypes of HIV-1 group M, between HIV-1 and HIV-2, and even between HIV-1 groups O and M, were confirmed at a rather high frequency (approximately 10%). The mixed infection is particularly significant where there is a greater variety of HIV-1 subtypes circulating, since it results in new genetic diversity generated by intersubtype recombination.
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ISSN:0042-6822
1096-0341
DOI:10.1006/viro.1998.9141