Chondrons and the Pericellular Matrix of Chondrocytes

In cartilage, chondrocytes are embedded within an abundant extracellular matrix (ECM). A typical chondron consists of a chondrocyte and the immediate surrounding pericellular matrix (PCM). The PCM has a patent structure, defined molecular composition, and unique physical properties that support the...

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Bibliographic Details
Published inTissue engineering. Part B, Reviews Vol. 21; no. 3; pp. 267 - 277
Main Author Zhang, Zijun
Format Journal Article
LanguageEnglish
Published United States Mary Ann Liebert, Inc 01.06.2015
Subjects
Animals
Cartilage
Cartilage - cytology
Cartilage - metabolism
Cell Differentiation - physiology
Cellular biology
Chondrocytes - cytology
Chondrocytes - metabolism
Chondrogenesis - physiology
Extracellular Matrix - metabolism
Humans
Tissue engineering
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Summary:In cartilage, chondrocytes are embedded within an abundant extracellular matrix (ECM). A typical chondron consists of a chondrocyte and the immediate surrounding pericellular matrix (PCM). The PCM has a patent structure, defined molecular composition, and unique physical properties that support the chondrocyte. Given this spatial position, the PCM is pivotal in mediating communication between chondrocytes and the ECM and, thus, plays a critical role in cartilage homeostasis. The biological function and mechanical properties of the PCM have been extensively studied, mostly in the form of chondrons. This review intends to summarize recent progress in chondron and chondrocyte PCM research, with emphasis on the re-establishment of the PCM by isolated chondrocytes or mesenchymal stem cells during chondrogenic differentiation, and the effects of the PCM on cartilage tissue formation.
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ISSN:1937-3368
1937-3376
1937-3376
DOI:10.1089/ten.teb.2014.0286