Risk of All-Cause Mortality, Recurrent Myocardial Infarction, and Heart Failure Hospitalization Associated With Smoking Status Following Myocardial Infarction With Left Ventricular Dysfunction

• Published in: The American journal of cardiology Vol. 106; no. 7; pp. 911 - 916
• Main Authors: Shah, Amil M., MD, Pfeffer, Marc A., MD, PhD, Hartley, L. Howard, MD, Moyé, Lemuel A., MD, PhD, Gersh, Bernard J., MD, MB, ChB, DPhil, Rutherford, John D., MD, Lamas, Gervasio A., MD, Rouleau, Jean L., MD, Braunwald, Eugene, MD, Solomon, Scott D., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.10.2010; Elsevier; Elsevier Limited
• Subjects: Adult; Biological and medical sciences; Cardiology; Cardiology. Vascular system; Cardiovascular; Clinical outcomes; Coronary heart disease; Female; Follow-Up Studies; Heart; Heart attacks; Heart failure; Heart Failure - etiology; Heart failure, cardiogenic pulmonary edema, cardiac enlargement; Hospitalization; Humans; Male; Medical sciences; Middle Aged; Myocardial Infarction - complications; Myocardial Infarction - mortality; Myocarditis. Cardiomyopathies; Recurrence; Risk Assessment; Risk Factors; Smoking; Smoking - adverse effects; Smoking Cessation; Tobacco, tobacco smoking; Toxicology; Ventricular Dysfunction, Left - etiology; Ventricular Dysfunction, Left - mortality; Myocardial infarction; Heart failure; Cardiac performance; Relapse; Prognosis; Mortality; Tobacco smoking; Cardiovascular disease; Risk; Heart ventricle; Hospitalization; Left ventricular failure; Recurrent; Coronary heart disease; Myocardial disease; Risk factor; Circulatory system; Cardiology; Left ventricle performance
• ISSN: 0002-9149; 1879-1913
• DOI: 10.1016/j.amjcard.2010.05.021

Patients with left ventricular (LV) systolic dysfunction after myocardial infarction (MI) are at particularly high risk for recurrent adverse outcomes. The magnitude of the decrease in risk associated with smoking cessation after MI has not been well described in patients with LV dysfunction after MI. We aimed to quantify the risk decrease associated with smoking cessation in subjects with LV dysfunction after MI. The Survival and Ventricular Enlargement (SAVE) trial randomized 2,231 subjects with LV dysfunction 3 to 16 days after MI. Smoking status was assessed at randomization and at regular intervals during a median follow-up of 42 months. Propensity score-adjusted Cox proportional hazard models were used to quantify the decrease in risk of all-cause mortality, death or recurrent MI, and death or heart failure (HF) hospitalization associated with smoking cessation. In baseline smokers who survived to 6 months without interval events, smoking cessation at 6-month follow-up was associated with a significantly lower adjusted risk of all-cause mortality (hazard ratio [HR] 0.57, 95% confidence interval [CI] 0.31 to 0.91), death or recurrent MI (HR 0.68, 95% CI 0.47 to 0.99), and death or HF hospitalization (HR 0.65, 95% CI 0.46 to 0.92). In conclusion, in patients with LV dysfunction after MI, smoking cessation is associated with a 40% lower hazard of all-cause mortality and a 30% lower hazard of death or recurrent MI or death or HF hospitalization. These findings indicate that smoking cessation is beneficial after high-risk MI and highlight the importance of smoking cessation as a therapeutic target in patients with LV dysfunction after MI.