The Role of Microglia in the Development of Neurodegenerative Diseases

Microglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial acti...

Full description

Saved in:
Bibliographic Details
Published inBiomedicines Vol. 9; no. 10; p. 1449
Main Authors Lee, Jae-Won, Chun, Wanjoo, Lee, Hee Jae, Kim, Seong-Man, Min, Jae-Hong, Kim, Doo-Young, Kim, Mun-Ock, Ryu, Hyung Won, Lee, Su Ui
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 12.10.2021
MDPI
Subjects
Alzheimer's disease
Animal models
Apoptosis
Central nervous system
Chemokines
Convulsions & seizures
Cytokines
Dementia
Epilepsy
Homeostasis
Huntington's disease
Huntingtons disease
inflammatory molecules
Microglia
microglial activation
Movement disorders
Neurodegeneration
Neurodegenerative diseases
Neurogenesis
neuronal damage
Neurons
Neuroprotection
Oxidative stress
Parkinson's disease
Plaques
Proteins
Review
Reviews
Online AccessGet full text

Cover

More Information
Summary:Microglia play an important role in the maintenance and neuroprotection of the central nervous system (CNS) by removing pathogens, damaged neurons, and plaques. Recent observations emphasize that the promotion and development of neurodegenerative diseases (NDs) are closely related to microglial activation. In this review, we summarize the contribution of microglial activation and its associated mechanisms in NDs, such as epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), and Huntington’s disease (HD), based on recent observations. This review also briefly introduces experimental animal models of epilepsy, AD, PD, and HD. Thus, this review provides a better understanding of microglial functions in the development of NDs, suggesting that microglial targeting could be an effective therapeutic strategy for these diseases.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
These authors contributed equally to this work.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines9101449